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About the MacArthur Lab

We are a tight-knit research group jointly based as Massachusetts General Hospital and the Broad Institute of Harvard and MIT, and leveraging the largest genomic data sets in the world and cutting-edge analysis methods to make sense of human genetic variation. We’re committed to open data and open-source code, as well as experimenting with new methods of communication. Working with us is a chance to learn from experts in computational biology, large-scale genomics, variant interpretation, software development and clinical genomics, as well as to make a difference to the lives of hundreds of families affected by rare diseases.


Clinical Project Coordinator

Our team is focused on applying genomic technologies to diagnose families affected by rare genetic diseases. To assist with these efforts, we are seeking an organized and motivated Clinical Project Coordinator (CPC) to work within the Broad Center for Mendelian Genomics (CMG) on the Rare Genomes Project (RGP). The RGP is our direct-to-patient genome sequencing initiative aimed at identifying the underlying genetic basis for rare and undiagnosed conditions affecting families from around the country. Our mission is to partner directly with patients, families, advocates, and clinicians to accelerate the rate of rare disease diagnosis and increase patients’ access to genomic research. We are seeking a motivated CPC who can help ensure that these efforts run smoothly and effectively. The CPC will have an important role in the RGP in coordination of patient participation in the project. Additionally, the CPC will work with a diverse team of software engineers, computational biologists, clinicians, analysts, and investigators, among others on our team. The ideal candidate for this position will be detail-oriented, comfortable talking with patients and families, enthusiastic about clinical research, and have a desire to continuously improve processes.

Primary responsibilities for the role include:

    • Serve as the primary telephone and email point of contact for applicants and participants in the project.
    • Communicate with families at various time points to facilitate enrollment and participation, including notification of acceptance into the project, the scheduling of consent appointments, and responding to participant questions at all stages of their participation.
    • Track applications, samples, and data collected as part of the project and compile project statistics on a routine basis.
    • Obtain, compile, and enter demographic, clinical, and other necessary study data into study databases.
    • Assist with obtaining medical records and samples from participants.
    • Participate in meetings of the MacArthur/Rehm Rare Disease Group, which includes the Rare Genomes Project.
    • Help improve processes and develop automation solutions as the project scales.
    • Contribute to other RGP-related efforts, which may include developing content updates for the website and patient recruitment materials, developing and maintaining an RGP Facebook page and/or other social media presence, assisting with the development of a patient portal, or IRB-related tasks.

Characteristics and Qualifications:

    • Bachelor’s Degree required.
    • Spanish-speaking a plus.
    • Must be very detail-oriented and extremely self-motivated, with the ability to effectively manage time and prioritize workload.
    • Excellent organization, communication, and time management skills required.
    • Strong interpersonal skills; ability to effectively interact with all levels of staff and external contacts.
    • Ability to work as part of a multidisciplinary team, in a fast-paced and challenging work environment and respond to shifting priorities.
    • Must possess a high level of initiative.
    • Experience working directly with patient populations and/or data management preferred.

Please apply via Broad Institute careers site.


Post-doctoral Fellows

We are looking for postdoc candidates with backgrounds in computational genomics or statistical genetics, ideally with direct experience in analyzing human sequencing data. Projects include identifying human knockouts, leveraging large human genetic data sets for drug target discovery, and improving the diagnosis of rare disease patients. Most importantly, we’re looking for people who are passionate about the translation of genomics into clinical practice, and have the right personality to work in a fast-paced and highly collaborative environment.

To apply, email Daniel with your CV.